TThe role of hypoxia-inducible factors in leukemias
نویسندگان
چکیده
منابع مشابه
Hypoxia and Hypoxia-Inducible Factors in Leukemias
Despite huge improvements in the treatment of leukemia, the percentage of patients suffering relapse still remains significant. Relapse most often results from a small number of leukemic stem cells (LSCs) within the bone marrow, which are able to self-renew, and therefore reestablish the full tumor. The marrow microenvironment contributes considerably in supporting the protection and developmen...
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Oxygen is vital to mammalian survival. Oxygen deprivation, defined as hypoxia, elicits adaptive responses in cells and tissues, a process regulated by proteins known as hypoxia-inducible factors (HIF). Animal studies have provided compelling data to demonstrate a pivotal role for the HIF pathway in the pathogenesis of acute kidney injury (AKI) that have led to initial human clinical trials exam...
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Chronic kidney disease (CKD), defined by loss of renal function, is highly prevalent, and imposes a large economic burden worldwide. Renal fibrosis is the final common pathway leading to CKD regardless of the initial insult. The extent of renal fibrosis is highly correlated with the severity of CKD. Understanding the pathophysiology of renal fibrosis is of paramount importance. Microscopically,...
متن کاملRole of Hypoxia-Inducible Factors in Acute Kidney Injury
Oxygen is vital to mammalian survival. Oxygen deprivation, defined as hypoxia, elicits adaptive responses in cells and tissues, a process regulated by proteins known as hypoxia-inducible factors (HIF). Animal studies have provided compelling data to demonstrate a pivotal role for the HIF pathway in the pathogenesis of acute kidney injury (AKI) that have led to initial human clinical trials exam...
متن کاملRole of Hypoxia-Inducible Factors in Acute Kidney Injury
Oxygen is vital to mammalian survival. Oxygen deprivation, defined as hypoxia, elicits adaptive responses in cells and tissues, a process regulated by proteins known as hypoxia-inducible factors (HIF). Animal studies have provided compelling data to demonstrate a pivotal role for the HIF pathway in the pathogenesis of acute kidney injury (AKI) that have led to initial human clinical trials exam...
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ژورنال
عنوان ژورنال: Advances in Clinical and Experimental Medicine
سال: 2018
ISSN: 1899-5276
DOI: 10.17219/acem/69261